Ms Giuffre, 41, who took her own life in 2025 at her farm in Western Australia, alleged she was forced to have sex on multiple occasions with former Duke of York Andrew Mountbatten-Windsor after Epstein trafficked her.
Her family have previously called for a public inquest into her death and a formal review of police actions they believe failed to protect her.
WA Police Commissioner Col Blanch on Wednesday confirmed Ms Giuffre's case would be reviewed after he received a letter from her family.
They have said Ms Giuffre may have been a victim of domestic violence in the lead-up to her death.
Mr Blanch was asked by an MP in WA Parliament whether he was confident police responded to Ms Giuffre's requests for help in the months before she died.
"I simply don't know," he said.
"We respond to over 100,000 family violence incidents every year, so I'd love to give assurance on every single one, but I can't.
"But that one will be subject to a review, and the coroner can also choose to do an investigation, as could the ombudsman."
Ms Giuffre settled a sexual assault lawsuit against the former prince, although he has always denied the allegations.
She also figured prominently in the downfall of Epstein, who was found dead in his New York jail cell in August 2019 while awaiting trial on sex trafficking charges. His death was ruled a suicide.
His former girlfriend, Ghislaine Maxwell, was convicted in late 2021 on sex trafficking and other charges.
1800 RESPECT (1800 737 732)
National Sexual Abuse and Redress Support Service 1800 211 028
Lifeline 13 11 14
beyondblue 1300 22 4636
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