The Broncos lock will likely have scans on the left ankle he injured in the 30-26 loss on Sunday at Suncorp Stadium.
Carrigan, who came off the bench in the Maroons' narrow 22-20 loss to NSW in Sydney on Wednesday night, has played 13 Origin games in a row since his 2022 debut.
He was solid off the bench in Sydney and it will be a major blow for Queensland if he is ruled out of game two in Melbourne on June 17.
Carrigan played the first 32 minutes of the clash with the Dragons before being replaced. He was on an exercise bike on the sideline early in the second half and then went back on before lasting just 10 minutes.
"It's some sort of ankle sprain," Broncos coach Michael Maguire said.
"Patty felt he was OK to go back out there, they assessed him and strapped him up, but you could just sense he was struggling a little bit."
The Maroons have options to replace middle forward Carrigan if he is ruled out.
Reuben Cotter played second-row in Sydney but is equally at home in the middle. Queensland could use him as a middle and elevate Dolphins second-rower Kulikefu Finefeuiaki, who was 20th man in game one.
North Queensland second-rower Heilum Luki is another option if they were to go down that path.
Finefeuiaki and Luki are yet to make their Origin debuts.
If the Maroons went with a straight middle replacement for Carrigan then Dolphins co-captain Tom Gilbert, Canberra warhorse Corey Horsburgh and Gold Coast prop Moeaki Fotuaika are all former Queensland players who could be called upon.
Horsburgh was outstanding up front in the Raiders' 26-12 win over the Cowboys on Sunday, when he ran for 165m from 18 charges. He was also defensively solid with 27 tackles and just one missed.
The Maroons selectors will pick the side after round 14 is completed this Sunday.
