Locked into a wildcard spot, the Magpies face a dilemma about how they approach Friday night's clash with the Lions at the MCG.
Due to finishing in the seventh to 10th bracket, Collingwood don't earn a week off heading into finals and will need to carefully manage their players this weekend.
Quaynor suffered a minor glute injury in Saturday night's thrilling draw against Hawthorn and has been ruled out.
Lipinski (calf) and Perryman (hamstring) were in contention to return, but won't take on the Lions.
Jeremy Howe (arm), Brayden Maynard (shoulder) and Steele Sidebottom (illness) will be assessed after training on Wednesday to decide whether they return.
Collingwood could opt to rest other players despite the AFL warning clubs against doing that in a memo sent by football boss Greg Swann.
The Lions have listed co-captain Hugh McCluggage (calf) as one week and will be a chance to be back for their first final.
At Port Adelaide, star Jason Horne-Francis has a broken toe and will miss the Power's season-closing match against Essendon on Sunday.
Despite pushing hard for a likely farewell match at Port, Zak Butters is almost no chance of returning to play the Bombers.
Butters is almost certainly leaving Port during the trade period with the Western Bulldogs, Collingwood, Geelong and Richmond fighting hard for his services.
Bombers ace Sam Durham has been ruled out of taking on the Power due to 'general soreness'.
If Essendon lose they will claim their first wooden spoon since 2016, giving them the No.1 pick in this year's draft.
After a bitterly disappointing year on the field, Gold Coast will finish off their season without star recruit Christian Petracca.
The former Melbourne star has an injured foot and won't feature in the Suns' dead-rubber against St Kilda on Thursday night.
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