The former prince - who was stripped of his titles in October - was arrested at his Sandringham home in February on suspicion of misconduct in public office following revelations in the Epstein Files released by the US government, and now his younger daughter has stepped away from the world's oldest human rights organisation.
"After seven years, our patronage from HRH Princess Eugenie of York has come to an end," Anti-Slavery International told The Observer in a statement.
"We thank the Princess very much for her support for Anti-Slavery International. We hope that she continues to work to end slavery for good and deliver freedom for everyone."
There is no suggestion of any wrongdoing by 35-year-old Eugenie, who has yet to comment on her father's arrest.
The princess's profile has been removed from Anti-Slavery International's website, which previously hailed her work "across the board with leaders in the fight against modern slavery".
Eugenie - who has sons August, five, and Ernest, two, with husband Jack Brooksbank - also works as a director of art gallery Hauser and Wirth, and co-founded another anti-slavery charity, Anti-Slavery Collective, with her friend Julia de Boinville in 2017.Â
Following Andrew's arrest, it was claimed Eugenie and her sister, Princess Beatrice - who has Sienna, four, and 13-month-old Athena with husband Edoardo Mapelli Mozzi and is stepmother to his nine-year-old son Wolfie - were focusing on "protecting their own children".
Andrew and his ex-wife Sarah Ferguson, the former Duchess of York, have faced increasing scrutiny over their friendship with the late convicted sex offender Jeffrey Epstein.