Jury selection is set to start as early as Tuesday in the one-time movie mogul's latest retrial, where jurors will weigh — for the third time — whether he raped hairstylist and actress Jessica Mann in a Manhattan hotel in 2013.
But "it's not going to be a mirror image of the last trial," new Weinstein lawyer Marc Agnifilo told Judge Curtis Farber in March.
This time, jurors will weigh only one charge based on one accuser, rather than the array of allegations that were aired at Weinstein's previous trials in New York and Los Angeles.
The Oscar-winning producer denies all the accusations and declared in court this winter that he had "acted wrongly, but I never assaulted anyone".
The judge has indicated he might revisit some rulings about exactly what evidence gets presented about Weinstein's and Mann's years of interactions. And Weinstein's recent change in lawyers could shift the trial's tenor and tactics.
Agnifilo and his partners took on the case only in February, when longtime Weinstein lawyer Arthur Aidala stepped aside from the retrial to focus on the former studio boss' appeals and civil matters.
Both Aidala and Agnifilo are well-known New York defence lawyers, but their litigation styles differ. Aidala is folksy, while Agnifilo is more buttoned-up.
Weinstein wielded significant clout in the entertainment industry, having built his reputation on such critical and popular hits as Shakespeare in Love, Pulp Fiction and Chocolat. He also became a prominent Democratic donor.
Then a series of sexual harassment and sex assault allegations against Weinstein began to emerge in news media in 2017, propelling the #MeToo movement.
He was criminally charged in New York in 2018 and in Los Angeles two years later.
Weinstein went to trial and was convicted of some — but not all — counts in both cases.
His initial New York convictions were overturned, spurring a retrial in 2025.
Mann has testified that she had a consensual, on-and-off relationship with the then-married Weinstein. But when he cornered her in a Manhattan hotel room where she was staying on a weekend getaway, she protested, "I don't want to do this," she told jurors. She said he kept making advances and demands until she "just gave up".
Weinstein hasn't testified at any of his trials, but his lawyers have contended that he never had non-consensual sex.
Weinstein suffers from various health problems and uses a wheelchair. He said in court in January that he is haunted by the possibility that he might die in New York's notorious Rikers Island jail.
"My mental state is collapsing … my spirit is breaking," he told the judge.
Weinstein's lawyers have argued that his New York conviction in 2025 was poisoned by bad blood among jurors. Meanwhile, he is appealing the Los Angeles verdict.