Among those were six motorists caught either drink driving or drug driving up to midnight on Tuesday, December 21.
Operation Roadwise started at 12.01am on Friday, December 17, and will run until midnight on Sunday, December 26.
Police Eastern Region Division Three tasking and co-ordination Acting Inspector Dave Gillespie said three collisions that caused injuries had occurred so far in the Greater Shepparton area.
Those injured include a 13-year-old Shepparton boy who was hit by a car on Friday, December 17.
Acting Insp Gillespie said the incident occurred at the intersection of Corio and Knight streets.
The boy was taken to hospital for observation.
A man from Faraday in central Victoria has been charged with reckless conduct endangering serious injury, two counts of driving in a manner dangerous, resisting police, refusing a breath test, failing to give a name and address and failing to render assistance.
Another two incidents occurred on Sunday, December 19.
Acting Insp Gillespie said one of them saw two vehicles collide on the Midland Hwy between Shepparton and Mooroopna at 8pm.
An occupant of one of the cars received a cut to his head, but was not taken to hospital.
A third crash saw two pedestrians hit by a car at the intersection of Fryers and Wyndham streets about 12.21am.
A 30-year-old woman and 40-year-old man, both from Shepparton, were taken to Goulburn Valley Health with lower leg injuries.
A 20-year-old woman from Kyabram is assisting police with their inquiries.
Acting Insp Gillespie is urging motorists to drive safely during the Christmas holidays.
He asked motorists to plan their trips and to be patient, so that everyone could get to their destination safely.
Acting Insp Gillespie also warned against drink or drug driving, with these two things among the focus of the police operation.
He also said people should report any poor driver behaviour they saw to police.
RoadSafe Goulburn Valley chair Des Callaghan urged people to take regular breaks, especially if they were on long trips, and not to drive at times when they would normally be asleep.
“Driver fatigue is one of the biggest contributors to road trauma,” Mr Callaghan said.
He also warned that motorists should be aware of what was happening around them, including watching for speed zone changes due to, for example, roadworks, as well as watching out for farmers who may be moving stock across roads or driving slow-moving farm machinery.
“Road safety doesn’t just stay with the police — it is every driver’s responsibility to drive safely,” Mr Callaghan said.