His representatives said Dane died from amyotrophic lateral sclerosis, known also as Lou Gehrig's disease, less than a year after he announced his diagnosis.
"He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the centre of his world," said a statement that requested privacy for his family.
"Throughout his journey with ALS, Eric became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight.
"He will be deeply missed, and lovingly remembered always. Eric adored his fans and is forever grateful for the outpouring of love and support he's received."
Dane was born on November 9, 1972 and raised in California. His father, a Navy man, died of a gunshot wound when he was seven.
After high school, he moved to Los Angeles to pursue acting, landing guest roles on shows like Saved by the Bell, Married...With Children, Charmed and X-Men: the Last Stand, and one season of the short-lived medical drama Gideon's Crossing.
His big break arrived in the mid-2000s, when he was cast as Dr Mark Sloan, aka McSteamy, on the US medical drama Grey's Anatomy, a role he would play from 2006 until 2012 and reprise in 2021.
In 2019, he did a complete 180 and became Cal Jacobs, a troubled married man, in HBO's provocative drama Euphoria, a role he continued in up until his death.
Dane also starred as Tom Chandler, the captain of a US Navy destroyer at sea after a global catastrophe wiped out most of the world's population, in the drama The Last Ship.
In 2017, production was halted as Dane battled depression.
In April 2025, Dane announced he had been diagnosed with ALS, the most common type of motor neurone disease, a progressive disease that attacks nerve cells controlling muscles throughout the body.
It gradually destroys the nerve cells and connections needed to walk, talk, speak and breathe. Most patients die within three to five years of a diagnosis.
Dane became an advocate for ALS awareness and in 2025 the ALS Network named Dane the recipient of their advocate of the year award, recognising his commitment to raising awareness and support for people living with the disease.
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