The Fed's quarter-point hike in its key rate, which it had pinned near zero since the pandemic recession struck two years ago, marks the start of its effort to curb the high inflation that has followed the recovery.
The rate hikes will eventually mean higher loan rates for many consumers and businesses.
The central bank's policymakers expect inflation to remain elevated and to end 2022 at 4.3 per cent, according to updated quarterly projections they released on Wednesday - far above the Fed's 2.0 per cent annual target.
The officials also now forecast much slower economic growth this year, of 2.8 per cent, down from its 4.0 per cent estimate in December.
Chair Jerome Powell is steering the Fed into a sharp U-turn.
Officials had kept rates ultra-low to support growth and hiring during the recession and its aftermath.
As recently as December, Fed officials had expected to raise rates just three times this year.
Now, its projected seven hikes would raise its short-term rate to 1.75 per cent at the end of 2022.
It could increase rates by a half-point at future meetings.
Fed officials also forecast four additional hikes in 2023, boosting its benchmark rate to 2.75 per cent - which would be the highest level since March 2008.
Borrowing costs for mortgage loans, credit cards and car loans will likely rise as a result.
Powell is hoping that the rate hikes will achieve a difficult and narrow objective: raising borrowing costs enough to slow growth and tame high inflation yet not so much as to topple the US economy into recession.
Yet many economists worry that with inflation already so high - it reached 7.9 per cent in February, the worst in four decades - and with Russia's invasion of Ukraine driving up petrol prices, the Fed may have to raise rates even higher than it now expects and potentially tip the economy into recession.
By its own admission, the US central bank underestimated the breadth and persistence of high inflation after the pandemic struck.
Many economists say the Fed made its task riskier by waiting too long to begin raising rates.
